Molecular Biology and Toxicology of Metals

Front Cover
Rudolfs K. Zalups, D. James Koropatnick
CRC Press, Feb 24, 2000 - Medical - 608 pages
Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.

From inside the book

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Contributors
1
Max Costa Nelson Institute of Environmental Medicine and Kaplan Comprehensive
30
Biochemical pathways in cadmium toxicity
34
Arsenic
75
Chromium and nickel
113
Transport of soft metals in procaryotes
129
Metal transport and metabolism
150
The role of ion channels in the transport of metals into excitable
179
Transport of metals in the gastrointestinal system and kidneys
300
Molecular mechanisms of hepatic metal transport
346
Role of glutathione in the metabolism transport and toxicity of metals
382
Role of metallothionein in the metabolism transport and toxicity
414
Metal ions and the cytoskeleton
460
The role of metals in oxidative damage and redox cellsignaling
477
Copper ion regulation of gene expression in yeast
528
Toxic and essential metals in the cellular response to signals
551

Responses of the respiratory tract to cadmium
208
molecular interactions and mimicry in the kidney
234
Transport of metals in the nervous system
276

Other editions - View all

Common terms and phrases

Popular passages

Page 574 - K. (1994) Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-KB and AP-1.
Page 573 - Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607-14.

References to this book

Bibliographic information