Molecular Biology and Toxicology of MetalsRudolfs K. Zalups, D. James Koropatnick Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology. |
From inside the book
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Contents
Biochemical pathways in cadmium toxicity 34 12 | 34 |
Arsenic 75 | 75 |
Chromium and nickel | 113 |
Transport of soft metals in procaryotes | 129 |
Metal transport and metabolism | 150 |
The role of ion channels in the transport of metals into excitable | 179 |
Responses of the respiratory tract to cadmium | 208 |
molecular interactions and mimicry in the kidney | 234 |
Molecular mechanisms of hepatic metal transport | 346 |
Role of glutathione in the metabolism transport and toxicity of metals | 382 |
Role of metallothionein in the metabolism transport and toxicity | 414 |
Metal ions and the cytoskeleton | 460 |
The role of metals in oxidative damage and redox cellsignaling | 477 |
Copper ion regulation of gene expression in yeast | 528 |
Toxic and essential metals in the cellular response to signals | 551 |
577 | |
Transport of metals in the nervous system | 276 |
Transport of metals in the gastrointestinal system and kidneys | 300 |
Common terms and phrases
accumulation activity apoptosis Applied Pharmacology arsenic arsenite ATPase Ballatori basolateral binding Biochemical Biochemistry Biological Chemistry bone brain Buchet Ca² Ca2+ channels cadmium cadmium-induced calcium channels Cancer Carcinogenesis carcinogenic Cd-MT Cd2+ cells cellular ceruloplasmin Cherian chloride chromium complex compounds concentrations copper Cu(I cysteine decreased domain dose effects Environmental enzymes epithelial excretion exposure function glutathione hemochromatosis hepatic hepatocytes Hg2+ human increased induced inhibition inorganic arsenic inorganic mercury interactions intestinal intracellular ion channels iron Journal of Biological kidney L-type levels ligands liver lung mammalian mechanisms membrane Menkes disease mercuric chloride metabolism metal ions metal-binding metallothionein methylation methylmercury mice Molecular molecules mutations neurons nickel osteoclasts oxidative pathway peroxidation Pharmacology Physiology plasma protein proximal tubule rabbit receptor renal role species Stillman structure studies thiols tissue toxicity Toxicol Toxicology Toxicology and Applied transcription factors transport tubular uptake urinary vesicles vitro vivo voltage-gated Waalkes Wilson disease Zalups zinc Zn(II