Molecular Biology and Toxicology of MetalsMolecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology. |
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Contents
Contributors | 1 |
Max Costa Nelson Institute of Environmental Medicine and Kaplan Comprehensive | 30 |
Biochemical pathways in cadmium toxicity | 34 |
Arsenic | 75 |
Chromium and nickel | 113 |
Transport of soft metals in procaryotes | 129 |
Metal transport and metabolism | 150 |
The role of ion channels in the transport of metals into excitable | 179 |
Transport of metals in the gastrointestinal system and kidneys | 300 |
Molecular mechanisms of hepatic metal transport | 346 |
Role of glutathione in the metabolism transport and toxicity of metals | 382 |
Role of metallothionein in the metabolism transport and toxicity | 414 |
Metal ions and the cytoskeleton | 460 |
The role of metals in oxidative damage and redox cellsignaling | 477 |
Copper ion regulation of gene expression in yeast | 528 |
Toxic and essential metals in the cellular response to signals | 551 |
Common terms and phrases
accumulation activity anion apoptosis Applied Pharmacology arsenic arsenite ATPase Ballatori basolateral membrane binding Biochemical Biochemistry Biological Chemistry bone brain Buchet cadmium-induced calcium channels Cancer carcinogenesis carcinogenic Cd-MT cellular ceruloplasmin chelating chemical Cherian chromium complex compounds concentrations copper Cu(I cysteine damage decreased dose effects enzymes epithelial cells excretion function gene expression glutathione hemochromatosis hepatic hepatocytes human increased induced inhibition inorganic arsenic inorganic mercury interaction intestinal intracellular involved ion channels iron Journal of Biological kidney L-type levels ligands lipid liver lung mammalian mechanisms Menkes disease metabolism metal ions metallothionein methylation methylmercury mice Molecular molecules mouse mutations neurons nickel organic osteoclasts oxidative oxygen pathway peroxidation Pharmacology plasma protein proximal tubule rabbit receptor regulation renal response role species studies subunits thiols tissue toxicity Toxicol Toxicology Toxicology and Applied transcription factors transport tubular tumor uptake urinary vesicles vitro vivo voltage-gated Waalkes Wilson disease Zalups zinc
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Bibliographic information
| Title | Molecular Biology and Toxicology of Metals |
| Editors | Rudolfs K. Zalups, D. James Koropatnick |
| Edition | illustrated |
| Publisher | CRC Press, 2000 |
| ISBN | 0748407987, 9780748407989 |
| Length | 608 pages |
| Subjects | › › Medical / Toxicology Science / Chemistry / Toxicology Science / Life Sciences / Molecular Biology |
| Export Citation | BiBTeX EndNote RefMan |