Handbook of Pharmacology on AgingAs adaptive capacities decline, and disease increases, the elderly become major consumers of drugs. Because of the special needs of older patients, physicians, geriatricians, health providers, and researchers must know how the aging process changes the pharmacokinetic and pharmacodynamic properties of drugs prescribed to the elderly. The Second Edition of this essential handbook is an up-to-date source that analyses the major drug groups, the disorders they treat, and the age-associated changes in cellular processes that affect drug action. Disorders prevalent in older people, such as Alzheimer's disease and Parkinson's disease, are examined in great detail. The book also discusses a wide range of drugs, including bronchodilators for asthma, nonsteroid anti-inflammatory drugs for arthritis, antibiotics, and treatments for cardiovascular disease, cancer, and mental disorders. The handbook also provides insight into future research problems dealing with the expanding aging population, their drug usage, and increasing adverse drug reactions. |
Common terms and phrases
absorption acetylcholine acid action activity adenylate cyclase administration adrenergic adult adverse age-associated age-related changes agents agonists alcohol alterations Alzheimer's disease anemia anticoagulation antidepressants antipsychotic drugs associated bile acid sequestrants bleeding blood flow blood pressure brain cancer cardiac cardiovascular cells cholinergic chronic clearance Clin clinical cognitive concentration coronary decrease dementia digoxin disorders diuretics dopamine dose double-blind effects of aging elderly patients elimination enzyme erythromycin erythropoietin ethanol excreted factors function G protein gastrointestinal geriatric Gerontol half-life heparin hepatic HMG CoA reductase human hypertension impaired increase infections inhibition inhibitors interactions LDL cholesterol levels lipoprotein liver lovastatin mechanisms metabolism metabolite muscarinic receptors myelosuppression neurons neurotransmitter normal NSAIDs oral oxidative pharmacodynamic pharmacokinetics Pharmacol Pharmacology physiological plasma produce protein binding reduced reported response rHuEpo risk serum side effects signal transduction significant ẞ-adrenergic studies substantia nigra synthesis tetracyclines theophylline Ther therapeutic therapy tissue toxicity treatment trial tumor vascular warfarin young