Infection and AutoimmunityYehuda Shoenfeld, Nancy Agmon-Levin, Noel R. Rose Infection and Autoimmunity encompasses the different mechanisms involved in the infection-autoimmunity association/induction. Special attention is given to heat shock proteins (HSPs) and to transgenic mouse models to better understand infection-induced autoimmunity. Organized into six parts, this book first discusses the mechanisms of autoimmune induction by infection. Some chapters follow discussing the vaccination and vaccines, including the controversial issue of vaccine-autoimmunity relationship. Other chapters elucidate the relationship of bacteria and parasites to autoimmunity. Lastly, the aspects of infections and diseases are described. This reference material will help readers gain a deeper insight into the important etiological aspects of autoimmunity.
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From inside the book
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Page 9
... Molecular mimicry has been widely utilized to describe the specialized case where TCR crossreactivity involves peptides from an infectious agent and a self-antigen. 4. ACTIVATION OF MBP SPECIFICT CELLS BY NATURALLY PROCESSED VIRAL ...
... Molecular mimicry has been widely utilized to describe the specialized case where TCR crossreactivity involves peptides from an infectious agent and a self-antigen. 4. ACTIVATION OF MBP SPECIFICT CELLS BY NATURALLY PROCESSED VIRAL ...
Page 14
... molecular mimicry in this disease process, a single amino acid substitution was made in the crossreactive T cell epitope of the viral UL-6 protein. The mimicry T cell epitope was found to be important for disease induction in C.AL-20 ...
... molecular mimicry in this disease process, a single amino acid substitution was made in the crossreactive T cell epitope of the viral UL-6 protein. The mimicry T cell epitope was found to be important for disease induction in C.AL-20 ...
Page 17
... molecular mimicry model of multiple sclerosis. J Clin Invest 2001;108:311–8. Olson JK, Eagar TN, Miller SD. Functional activation of myelin-specific T cells by virus-induced molecular mimicry. J Immunol 2002; 169.2719–26 ...
... molecular mimicry model of multiple sclerosis. J Clin Invest 2001;108:311–8. Olson JK, Eagar TN, Miller SD. Functional activation of myelin-specific T cells by virus-induced molecular mimicry. J Immunol 2002; 169.2719–26 ...
Page 26
... molecular mimicry, etc.) [70a, 70b, 72-77]. Interestingly, tolerization of lupus-prone mice against either autoantibodyderived peptides or the protein/peptides (e.g., nucleosomal peptides) representing antigenic determinants involved in ...
... molecular mimicry, etc.) [70a, 70b, 72-77]. Interestingly, tolerization of lupus-prone mice against either autoantibodyderived peptides or the protein/peptides (e.g., nucleosomal peptides) representing antigenic determinants involved in ...
Page 40
... Molecular Mimicry in. 94. 95. 96. 97. 98. 99. Let al. Early-onset myasthenia gravis: a recurring Tcell epitope in the adult-specific acetylcholine receptor epsilon subunit presented by the susceptibility allele HLA-DR52a. Ann Neurol 1999 ...
... Molecular Mimicry in. 94. 95. 96. 97. 98. 99. Let al. Early-onset myasthenia gravis: a recurring Tcell epitope in the adult-specific acetylcholine receptor epsilon subunit presented by the susceptibility allele HLA-DR52a. Ann Neurol 1999 ...
Contents
1 | |
5 | |
85 | |
121 | |
Bacteria and Autoimmunity | 319 |
Parasites and Autoimmunity | 437 |
Infection and Diseases | 471 |
Subject Index | 741 |
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Infection and Autoimmunity Yehuda Shoenfeld,Nancy Agmon-Levin,Noel Richard Rose,Y. Shoenfeld Limited preview - 2004 |
Common terms and phrases
activation acute agents animals anti antibodies antigens arthritis Arthritis Rheum associated autoantibodies autoimmune disease bacterial binding blood cause cells chronic Clin clinical clones common complex controls cross-reactive cytokines damage demonstrated detected determined diabetes effects epitope et al evidence experimental expression factor frequency function gene genetic heart hepatitis host human immune response Immunol important increased individuals induced infection inflammatory initial involved lead levels liver lymphocytes major mechanisms mice molecular mimicry molecules multiple sclerosis myocarditis myosin Nature normal observed occur pathogenesis patients peptide peripheral persistent possible present production protein pylori reactive recent receptor recognized reported rheumatic fever risk role sequence serum severe showed shown similar specific spreading stimulation suggested syndrome synovial fluid T-cell therapy thyroid tion tissue treatment trigger type 1 diabetes vaccine vasculitis viral viral infection virus viruses
Popular passages
Page 147 - Navarro for their help in preparing the manuscript. This work was supported in part by CONACyT, Mexico and Fundacion RJ Zevada.
Page 54 - T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990; 346: 183-1 87.
Page 287 - Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.
Page 147 - Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001;182:18-32.
Page 283 - Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome Iq in African-American pedigrees. Proc Natl Acad Sci USA 1998:95(25): 14869-14874.
Page 168 - Wucherpfennig KW, Strominger JL 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein.
Page 72 - Ledbetter JA, Evans RL, Lipinski M, Cunningham-Rundles C, Good RA, Herzenberg LA: Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man.
Page 607 - A randomized trial comparing intravenous immune globulin and plasma exchange in Guillain-Barre syndrome.
Page 529 - Jerne NK, Towards a network theory of the immune system.
Page 245 - BURGESS, JA : High frequency of diabetes mellitus in young adults with congenital rubella.