Infection and AutoimmunityYehuda Shoenfeld, Nancy Agmon-Levin, Noel R. Rose Infection and Autoimmunity encompasses the different mechanisms involved in the infection-autoimmunity association/induction. Special attention is given to heat shock proteins (HSPs) and to transgenic mouse models to better understand infection-induced autoimmunity. Organized into six parts, this book first discusses the mechanisms of autoimmune induction by infection. Some chapters follow discussing the vaccination and vaccines, including the controversial issue of vaccine-autoimmunity relationship. Other chapters elucidate the relationship of bacteria and parasites to autoimmunity. Lastly, the aspects of infections and diseases are described. This reference material will help readers gain a deeper insight into the important etiological aspects of autoimmunity.
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Page 8
... activation of MBP-specific T cells [9]. Based on these considerations, we developed the hypothesis that TCR ... activated by this HLA-DR2/MBP peptide complex could thus provide insights into disease mechanisms in MS. We defined the ...
... activation of MBP-specific T cells [9]. Based on these considerations, we developed the hypothesis that TCR ... activated by this HLA-DR2/MBP peptide complex could thus provide insights into disease mechanisms in MS. We defined the ...
Page 9
... activated a MBP specific T cell clone that recognized both MBP and EBV DNA polymerase peptides. T cell activation was blocked by a mAb specific for HLA-DR but not by a control mAb against HLA-DQ, and was not observed when MHC-mismatched ...
... activated a MBP specific T cell clone that recognized both MBP and EBV DNA polymerase peptides. T cell activation was blocked by a mAb specific for HLA-DR but not by a control mAb against HLA-DQ, and was not observed when MHC-mismatched ...
Page 12
... activate human MBP specific T cell clones Organism Source protein Sequence Peptides that activate T cell clone Ob. 1A12 (HLA-DR2 restricted) Homo sapiens Myelin basic protein ENPVVHFFKNIVTPR Staphylococcus aureus VgaB VLARLHFYRNDVHKE ...
... activate human MBP specific T cell clones Organism Source protein Sequence Peptides that activate T cell clone Ob. 1A12 (HLA-DR2 restricted) Homo sapiens Myelin basic protein ENPVVHFFKNIVTPR Staphylococcus aureus VgaB VLARLHFYRNDVHKE ...
Page 14
... activation of the innate immune system was sufficient when large numbers of such T cells were already present. This model therefore clarified the potential contributions of TCR crossreactivity and 'bystander activation in the induction ...
... activation of the innate immune system was sufficient when large numbers of such T cells were already present. This model therefore clarified the potential contributions of TCR crossreactivity and 'bystander activation in the induction ...
Page 22
... activation of the disease was associated with intramolecular spreading to epitope 100–120 of MBP [17]. No inter-molecular spreading was observed during the course of reactivated disease. In another set of experiments by the same ...
... activation of the disease was associated with intramolecular spreading to epitope 100–120 of MBP [17]. No inter-molecular spreading was observed during the course of reactivated disease. In another set of experiments by the same ...
Contents
1 | |
5 | |
85 | |
121 | |
Bacteria and Autoimmunity | 319 |
Parasites and Autoimmunity | 437 |
Infection and Diseases | 471 |
Subject Index | 741 |
Other editions - View all
Infection and Autoimmunity Yehuda Shoenfeld,Nancy Agmon-Levin,Noel Richard Rose,Y. Shoenfeld Limited preview - 2004 |
Common terms and phrases
activation acute agents animals anti antibodies antigens arthritis Arthritis Rheum associated autoantibodies autoimmune disease bacterial binding blood cause cells chronic Clin clinical clones common complex controls cross-reactive cytokines damage demonstrated detected determined diabetes effects epitope et al evidence experimental expression factor frequency function gene genetic heart hepatitis host human immune response Immunol important increased individuals induced infection inflammatory initial involved lead levels liver lymphocytes major mechanisms mice molecular mimicry molecules multiple sclerosis myocarditis myosin Nature normal observed occur pathogenesis patients peptide peripheral persistent possible present production protein pylori reactive recent receptor recognized reported rheumatic fever risk role sequence serum severe showed shown similar specific spreading stimulation suggested syndrome synovial fluid T-cell therapy thyroid tion tissue treatment trigger type 1 diabetes vaccine vasculitis viral viral infection virus viruses
Popular passages
Page 147 - Navarro for their help in preparing the manuscript. This work was supported in part by CONACyT, Mexico and Fundacion RJ Zevada.
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Page 287 - Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.
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Page 283 - Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome Iq in African-American pedigrees. Proc Natl Acad Sci USA 1998:95(25): 14869-14874.
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Page 245 - BURGESS, JA : High frequency of diabetes mellitus in young adults with congenital rubella.