Viral Pathogenesis, Volume 813Neal Nathanson, Rafi Ahmed Here is the most complete reference devoted specifically to viral pathogenesis, describing both the development of viral disease and the host/virus interaction. Presenting contributions from leading authorities in this particularly topical field, this comprehensive text exposits the current knowledge on the pathogenesis of viruses, an understanding of which is critical to treatment and prevention of viral diseases. The book opens with a thorough review of principles, covering in detail the life cycle of viruses, including entry, dissemination, shedding and transmission, and replication; the pathology of viral disease, including disease mechanisms, virus virulence, and viral oncogenesis; immune responses, including immune suppression; and therapeutic applications. The second section focuses on experimental pathogenesis, covering detection and quantification of viral genomes, messages, and proteins in tissues and organs; and examining classical and new methods for animal studies. Chapters in the next section, devoted to classical models of viral pathogenesis, cover ectromelia, poliomyelitis, rabies, lymphocytic choriomeningitis virus, avian and murine retroviruses, lentiviruses, and reoviruses. The final section covers systems pathogenesis, emphasizing viral diseases of humans but also drawing on animal studies that elucidate the pathogenesis of human infections. |
Contents
Introduction and History | 3 |
Entry Dissemination Shedding and Transmission of Viruses | 13 |
Localization of Viral Infections | 35 |
Copyright | |
35 other sections not shown
Other editions - View all
Viral Pathogenesis: From Basics to Systems Biology Michael Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson No preview available - 2016 |
Common terms and phrases
Acad Sci USA acid activation acute agents animals antibody antigen antiviral associated binding Biol blood cause cell culture cells cellular changes complex contain culture cytoplasm determinants disease early effects encodes enhancer et al example expression factor flavivirus function gene genetic genome glycoprotein growth hepatitis herpes simplex host human immune immunodeficiency Immunol important increased induced influenza inhibits initiation interaction involved isolates kinase lead leukemia levels lines lymphocytes macrophages major measles mechanisms membrane mice mosquito mouse murine mutations Natl Acad Sci natural occur oncogene papillomavirus patients persistent poliovirus present Proc Natl Acad production promoter protection protein receptor region replication resistance response result role selection sequence shown specific spread strains structure studies synthesis T-cell tion tissue transcription transformation transmission tumor vaccine variants vector viral virions Virol Virology virulence virus infection viruses vitro vivo