Advances in Molecular ToxicologyAdvances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed
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Page 29
... analogs rosiglitazone, pioglitazone, buspirone and trazodone (the latter associated with less frequent hepatotoxic events as compared to nefazodone). These compounds have to be assessed in parallel to their ''problematic'' comparators ...
... analogs rosiglitazone, pioglitazone, buspirone and trazodone (the latter associated with less frequent hepatotoxic events as compared to nefazodone). These compounds have to be assessed in parallel to their ''problematic'' comparators ...
Page 32
... analogs pioglitazone and rosiglitazone are also prone to reactive metabolite formation non-labeled via drugs TZD ... analog– but involved TZD ring-scission affording a disulfide-type glutathione adduct. T4 exhibited a 3 amu difference in ...
... analogs pioglitazone and rosiglitazone are also prone to reactive metabolite formation non-labeled via drugs TZD ... analog– but involved TZD ring-scission affording a disulfide-type glutathione adduct. T4 exhibited a 3 amu difference in ...
Page 33
... analogs. (A) Sequential metabolism of TZD drugs via TZD ring-scission involving loss of labeled positions during ... analog. Pioglitazone undergoes predominantly hydroxylation of the ethyl side chain by P450 3A4 and 2C8 followed by ...
... analogs. (A) Sequential metabolism of TZD drugs via TZD ring-scission involving loss of labeled positions during ... analog. Pioglitazone undergoes predominantly hydroxylation of the ethyl side chain by P450 3A4 and 2C8 followed by ...
Page 35
... analogs of rosiglitazone and pioglitazone (Figure 4A). The mixed-disulfide GSH conjugates of the amide type derived from pioglitazone (P2 Figure 8) and rosiglitazone (R2 Figure 9) exhibited a 3 amu difference in molecular weight SG O ...
... analogs of rosiglitazone and pioglitazone (Figure 4A). The mixed-disulfide GSH conjugates of the amide type derived from pioglitazone (P2 Figure 8) and rosiglitazone (R2 Figure 9) exhibited a 3 amu difference in molecular weight SG O ...
Page 36
... analogs. TZD-dependent bioactivation occurs for all TZD drugs in rat and human liver microsomes. Studies from our group and others have revealed that rosiglitazone and pioglitazone are also prone to form reactive intermediates at higher ...
... analogs. TZD-dependent bioactivation occurs for all TZD drugs in rat and human liver microsomes. Studies from our group and others have revealed that rosiglitazone and pioglitazone are also prone to form reactive intermediates at higher ...
Contents
1 | |
25 | |
Chapter 3 GlucuronidationDependent Toxicity and Bioactivation | 57 |
Chapter 4 Allergic Contact Dermatitis A Common Skin Disease Caused by Allergic Reactions to Chemicals in Our Environment | 87 |
Chapter 5 Inorganic Molecular Toxicology and Chelation Therapy of Heavy Metals and Metalloids | 123 |
Chapter 6 Pyrimidine Damage and Repair | 153 |
Chapter 7 Formation Persistence and Significance of DNA Adduct Formation in Relation to Some Pollutants from a Broad Perspective | 183 |
Subject Index | 241 |
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Common terms and phrases
A.T. Karlberg activity acyl glucuronide adduct levels allergy amines amino analogs aristolochic acid aromatic arsenic base bile bioactivation Biochem Biochemistry Biol biological biomarkers biotransformation BSEP buspirone cancer carcinogen Carcinogenesis cells cellular chelation Chem chemical cholestasis cholestatic chromate chromium clinical compounds contact allergens Contact Dermatitis covalent binding cytosine deamination diclofenac Dispos DNA adduct DNA damage DNA glycosylase dose Drug Metab effects electrophilic enzymes excretion exposure Figure gene genetic genotoxic genotype glucuronide glucuronide conjugates glutathione GSTM1 guanine hepatic hepatocytes hepatotoxicity human hydrogen hydroperoxides induced interactions intestinal irinotecan L.C. Sowers lesions liver mechanism mercury metabolism metabolites metal microsomes molecules Mrp2 mutagenic Mutat nefazodone Nucleic Acids nucleophilic oxidation pathway Pharmacol polymorphism potential protein pyrimidines radical rats reactions reactive metabolites role rosiglitazone selenium skin sensitization species structure studies substrate thymine tissue toxicity Toxicol Toxicology trazodone troglitazone tumour uracil vitro vivo workers
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