Advances in Molecular Toxicology, Volume 2Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed
|
From inside the book
Results 1-5 of 33
Page v
... Contact Dermatitis — A Common Skin Disease Caused by Allergic Reactions to Chemicals in Our Environment Ann-Therese Karlberg, Jens Baron and Hans Merk vii 25 25 29 47 49 52 3. 57 57 59 60 64 68 70 77 77 4. 87 Contents vi 5. Activation ...
... Contact Dermatitis — A Common Skin Disease Caused by Allergic Reactions to Chemicals in Our Environment Ann-Therese Karlberg, Jens Baron and Hans Merk vii 25 25 29 47 49 52 3. 57 57 59 60 64 68 70 77 77 4. 87 Contents vi 5. Activation ...
Page ix
... contact dermatitis affects a significant portion of the population and derives from contact with agents as simple as metal ions to molecules such as fragrance constituents. The molecular basis for this reaction is only recently becoming ...
... contact dermatitis affects a significant portion of the population and derives from contact with agents as simple as metal ions to molecules such as fragrance constituents. The molecular basis for this reaction is only recently becoming ...
Page x
... contact dermatitis, is the subject of Chapter 4 authored by Ann-Therese Karlberg, Jens Baron and Hans Merk. The stimulating complexity of the toxicology of metals and metalloids is the subject of Chapter 5 authored by Graham George ...
... contact dermatitis, is the subject of Chapter 4 authored by Ann-Therese Karlberg, Jens Baron and Hans Merk. The stimulating complexity of the toxicology of metals and metalloids is the subject of Chapter 5 authored by Graham George ...
Page 86
You have reached your viewing limit for this book.
You have reached your viewing limit for this book.
Page 87
You have reached your viewing limit for this book.
You have reached your viewing limit for this book.
Contents
1 | |
25 | |
Chapter 3 GlucuronidationDependent Toxicity and Bioactivation | 57 |
Chapter 4 Allergic Contact Dermatitis A Common Skin Disease Caused by Allergic Reactions to Chemicals in Our Environment | 87 |
Chapter 5 Inorganic Molecular Toxicology and Chelation Therapy of Heavy Metals and Metalloids | 123 |
Chapter 6 Pyrimidine Damage and Repair | 153 |
Chapter 7 Formation Persistence and Significance of DNA Adduct Formation in Relation to Some Pollutants from a Broad Perspective | 183 |
Subject Index | 241 |
Other editions - View all
Common terms and phrases
A.T. Karlberg activity acyl glucuronide adduct levels allergy amines amino analogs aristolochic acid aromatic arsenic base bile bioactivation Biochem Biochemistry Biol biological biomarkers biotransformation BSEP buspirone cancer carcinogen Carcinogenesis cells cellular chelation Chem chemical cholestasis cholestatic chromate chromium clinical compounds contact allergens Contact Dermatitis covalent binding cytosine deamination diclofenac Dispos DNA adduct DNA damage DNA glycosylase dose Drug Metab effects electrophilic enzymes excretion exposure Figure gene genetic genotoxic genotype glucuronide glucuronide conjugates glutathione GSTM1 guanine hepatic hepatocytes hepatotoxicity human hydrogen hydroperoxides induced interactions intestinal irinotecan L.C. Sowers lesions liver mechanism mercury metabolism metabolites metal microsomes molecules Mrp2 mutagenic Mutat nefazodone Nucleic Acids nucleophilic oxidation pathway Pharmacol polymorphism potential protein pyrimidines radical rats reactions reactive metabolites role rosiglitazone selenium skin sensitization species structure studies substrate thymine tissue toxicity Toxicol Toxicology trazodone troglitazone tumour uracil vitro vivo workers
Popular passages
Page 114 - Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (This) and Th2s.
Page 149 - Molecular mimicry in virus infection: Crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Proc. Natl. Acad. Sci.
Page 117 - Are free radicals and not quinones the haptenic species derived from urushiols and other contact allergenic mono- and dihydric alkylbenzenes? The significance of NADH, glutathione, and redox cycling in the skin. Arch Dermatol Res 1990; 282:56-64.
Page 120 - Schuler, G. (1996) Generation of mature dendritic cells from human blood: an improved method with special regard to clinical applicability. J. Immunol. Methods 196, 137-151.
Page 79 - Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?, Drug Metab.
Page 20 - H2O2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors. Arch. Biochem. Biophys.
Page 84 - WHO cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up.
Page 53 - Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission. Chem. Res. Toxicol. 14, 62-70. Kennett, DJ, and Winterhalder, B. (2006). "Behavioral Ecology and the Transition to Agriculture.
Page 227 - Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
Page 114 - Cher, DJ, and Mosmann, TR (1987) Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J. Immunol.