DAY OF DISEASE MEDICAL MISCELLANY. ST. LOUIS EMERGENCY CITY HOSPITAL, No. 2. Temperature, Pulse and Respiration Chart. No. 4732. Three weeks prior to entering the hospital, patient had a chill which recurred every second day, bowels loose and appetite poor. He was emaciated and presented a distinct cachexia. Liver and spleen both enlarged. In this case, as in the others, phenalgin controlled the disease and the patient was discharged well in ten days. ST. LOUIS EMERGENCY CITY HOSPITAL, No. 2. Temperature, Pulse and Respiration Chart. No. 4849. Had been having dizzy spells. On one occasion he fell down and was put to bed. Temperature developed and two days later he had a distinct chill. He was sent to the hospital for treatment after this chill and on the day after admission, a chill developed, followed by symptoms of malarial toxemia. Bacteriological report was positive. Quinine and phe MEDICAL MISCELLANY. nalgin were administered in ten grain doses t. i. d. No chill was perceptible the next day and the temperature gradually diminished and the patient discharged well in a week. ST. LOUIS EMERGENCY CITY HOSPITAL, No. 2. Temperature, Pulse and Respiration Chart. TIME Name Fuerstenberg DAY TAKER PULSE RESP. Sept 24 2468 2468 2468|2468|2468|2468|2468|2464|2468|2468|2468|24632468 Bed Bed No. 4856. Trouble began five or six weeks previous to entering the hospital. Patient had chills, loss of appetite, constipation and complained of pain all over the body. Had a chill at midnight of the day admitted, and in the morning there was a slight rise in the temperature. The chart showed a sub-normal temperature for several days, but, under the treatment instituted in the previous case, this returned to normal on the fifth day, and the patient was discharged well. DAY OF DISEASE (ST. LOUIS EMERGENCY CITY HOSPITAL, No. 2. Temperature, Pulse and Respiration Chart. No. 4920. This patient entered the hospital under observation for insanity. He developed a severe chill with typical malarial symptoms and the bacteriological report showed a positive MEDICAL MISCELLANY. reaction. In this case phenalgin was administered alone in gr.x doses and the patient discharged well in six days. DAY OF DISEASE ST. LOUIS EMERGENCY CITY HOSPITAL, No. 2. Temperature, Pulse and Respiration Chart. No 4941 TIME MONTH DAY TAKEN um • Sept 112/31 12 13 No. 4941. Diagnosis Malaria. Trouble began two weeks previous to admission to the hospital. Had the usual chills and loss of appetite, bowels constipated, some nausea and dizziness. Spleen and liver were slightly enlarged. On the fourth day after admission, he had a chill, followed by high temperature. The treatment followed in 4849, was administered in this case and the disease gradually disappeared, the patient being discharged well within a week. CASE VI. (No Chart.) Patient entered hospital in the evening, having had chill at 11 a. M. The usual symptoms of malarial toxemia were present and the blood examination showed the presence of plasmodium. The patient declared she could not take quinine, to quote her own language, "I just will not tak that quinine," phenalgin was, therefore, administered in five grain doses t. i. d. In addition to this, she was given the stock mixture of quinine, iron and strychnine, 4 cc. t. i. d. At the end of the third day there was considerable elevation of temper ture, the thermometer showing 105° F. following a chill. The phenalgin was increased to 10 grs. The day following there was a chill and a temperature, and on the eighth day after admission it became subnormal, registering 97° F. The dose of phenalgin was then diminished to grs. v, and on the tenth day after admission, she was discharged well. We know that large doses of quinine are usually necessary for controlling the paroxysms of malarial fever, but, in this case only two grains were given as contained in the tonic mixture, together with phenalgin. From a considerable experience with phenalgin, we may conclude that it possesses valuable antimalarial properties in addition to its being by far the best antipyretic and analgesic in general use. In it the various details of scientifically preparing cow's milk for an infant's digestion are discussed and many formulas given. It is printed in two colors on fine paper, is fully and beautifully illustrated and bound in full cloth. It will make a useful and valuable addition to your library. We have already supplied nearly 75,000 physicians. MELLIN'S FOOD COMPANY, BOSTON, MASS. EXODIN, A NEW PURGATIVE. BY PROF. WILHELM EBSTEIN. From the Gottingen University Medical Clinic; read before the Gottingen Medical Society, Dec. 3, 1903; abstracted from the Deutsche Medizinische Wochenschrift, Jan. 1, 1904. Exodin, the diacetylrufigallic-acid-tetramethyl-ether, is a yellow powder melting at 180 to 190° C. It is odorless and tasteless, insoluble in water and with difficulty dissolved in alcohol. Since January 13, 1903, I have experimented with it very extensively in the University and in my private clinic as well as in consulting practice. This paper is based upon numerous histories of more or less obstinate constipations in males and females of all ages. The remedy never causes unpleasant by-effects, such as dyspeptic symptoms or eructations. It usually acts in from eight to twelve hours. The unpleasant diarrhoeal discharges produced by many otherwise effective purgatives are absent with Exodin. In most cases the first passages are mushy and even solid. In the course of the next few hours there are usually from one to three more passages, the last being not infrequently thin. The fæces preserve their natural color. In extremely rare cases the first evacuations are diarrhoeal; entirely watery discharges were hardly ever observed. Once in a while the remedy may be ineffectual, but this is wholly exceptional. The action of Exodin is midway between laxative and purgative. It can be used as an evacuant in simple constipation in otherwise healthy persons and also when sluggishness of the bowels is an accidental complication or a part of some other affection. In pregnancy, even during the first two months, Exodin has when all other laxatives failed, proved very efficacious and harmless, effecting evacuation of abundant stools without any trouble. The use of the drug at intervals showed that it is always equally active whenever readministered. (A table here appended shows the action of the drug in eighteen typical cases.) For obvious reasons, a universal purgative suitable for all fæcal retentions will probably never be discovered. But the properties which Exodin exhibits enable me to welcome it as a most valuable purgative. |