Experimental Models of Multiple Sclerosis

Front Cover
Ehud Lavi, Cris S. Constantinescu
Springer Science & Business Media, Jan 3, 2008 - Medical - 902 pages

Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.

From inside the book

Contents

Eli BenChetrit and Stefan Brocke
10
A3 Histopathology of EAE
25
Myelin genes proteins and
45
A5 Adjuvants in EAE
73
A6 The role of astrocytes in autoimmune disease of the central
85
A7 Role of microglia and macrophages in EAE
109
A8 The Neuron and axon in EAE 133
132
A9 Endothelial cells and adhesion molecules in EAE
151
A27 EAE in primates
561
B1 Histopathology in the Theilers virus model of demyelination 579
578
myelin genes and proteins
593
B3 The role of astrocytes oligodendrocytes microglia and
617
B4 Immunogenetics resistance and susceptibility to Theilers
629
B5 The role of T cells and the innate immune system in Theilers
645
B6 Cytokines chemokines and adhesion molecules in 659
658
B7 Molecular determinants of TMEV pathogenesis
673

A10 Genetics of EAE
180
Insights into the development and
201
A12 The role of complement in EAE 245
244
A13 B cells and antibodies in EAE
269
A14 Cytokines in EAE 283
282
A15 The role of interferons in EAE
313
A16 The role of growth factors in EAE
343
A17 The chemokine system in EAE 363
362
A18 Free radicals and EAE
379
A19 Proteases and peptidases in EAE
391
A20 The bloodbrainbarrier in EAE 415
414
altered peptide ligands
451
A22 The role of costimulation in EAE
471
A23 Epitope spreading in EAE
491
apoptosis of effector cells as a 507
506
A25 Environmental influences in EAE
523
A26 Hormonal and gender influences on EAE
547
B8 Nitric oxide in TMEV 685
684
B9 Theilers murine encephalomyelitis virus TMEVinduced
697
C1 Histopathology in coronavirusinduced demyelination
711
C2 The role of astrocytes microglia and endothelial cells in
717
C3 Axons and neurons in coronavirusindued demyelination 737
736
C4 The role of T cells in coronavirus induced demyelination
747
C5 The role of humoral immunity in mouse hepatitis virus 759
758
C6 The role of T cell epitopes in coronavirus infection
771
myelin proteins myelin 781
780
C9 Chemokines in coronavirusinduced demyelination 805
804
C10 Coronavirus receptors
821
C11 Apoptosis in MHVinduced demyelination
833
C13 Molecular determinants in coronavirus MHVinduced
849
D1 Semliki Forest Virusinduced demyelination
861
D2 The pathogenesis of canine distemper virus induced
871
Index 889
888
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