Experimental Models of Multiple SclerosisEhud Lavi, Cris S. Constantinescu Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it. |
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Results 1-5 of 74
... perivascular inflammatory demyelinating lesions in the CNS and an immunogenetically determined susceptibility . Clinical expression of the disease is obvious by neurological signs and can be easily quantified . The immune system of the ...
... perivascular cuff ' - an accumulation of leukocytes in the perivascular space , involving vessels of the neuropil , meninges or choroid plexus . This accumulation of leukocytes involves the processes of leukocyte margination , molecular ...
... perivascular cuffs of lymphocytes , macrophages and plasma cells . There is sharp demarcation at the margin of the lesion with normal myelinated tissue . Within the plaque there is gliosis , reduced oligodendrocytes and axonal loss ...
... perivascular cuffs at the margin of the affected area ( arrows ) . ( b ) In the Luxol fast blue stained section the extent of the demyelination of this area of peripheral spinal cord white matter can be seen relative to the normally ...
... perivascular cuff in affected spinal cord white matter . ( b ) Shows an area of peripheral spinal cord white matter ... perivascular cuffs extensive perivascular cuffing with extension into adjacent subarachnoid space and CNS parenchyma ...
Contents
10 | |
25 | |
45 | |
73 | |
A6 The role of astrocytes in autoimmune disease of the central | 85 |
A7 Role of microglia and macrophages in EAE | 109 |
A8 The Neuron and axon in EAE 133 | 132 |
A9 Endothelial cells and adhesion molecules in EAE | 151 |
A27 EAE in primates | 561 |
B1 Histopathology in the Theilers virus model of demyelination 579 | 578 |
myelin genes and proteins | 593 |
B3 The role of astrocytes oligodendrocytes microglia and | 617 |
B4 Immunogenetics resistance and susceptibility to Theilers | 629 |
B5 The role of T cells and the innate immune system in Theilers | 645 |
B6 Cytokines chemokines and adhesion molecules in 659 | 658 |
B7 Molecular determinants of TMEV pathogenesis | 673 |
A10 Genetics of EAE | 180 |
Insights into the development and | 201 |
A12 The role of complement in EAE 245 | 244 |
A13 B cells and antibodies in EAE | 269 |
A14 Cytokines in EAE 283 | 282 |
A15 The role of interferons in EAE | 313 |
A16 The role of growth factors in EAE | 343 |
A17 The chemokine system in EAE 363 | 362 |
A18 Free radicals and EAE | 379 |
A19 Proteases and peptidases in EAE | 391 |
A20 The bloodbrainbarrier in EAE 415 | 414 |
altered peptide ligands | 451 |
A22 The role of costimulation in EAE | 471 |
A23 Epitope spreading in EAE | 491 |
apoptosis of effector cells as a 507 | 506 |
A25 Environmental influences in EAE | 523 |
A26 Hormonal and gender influences on EAE | 547 |
B8 Nitric oxide in TMEV 685 | 684 |
B9 Theilers murine encephalomyelitis virus TMEVinduced | 697 |
C1 Histopathology in coronavirusinduced demyelination | 711 |
C2 The role of astrocytes microglia and endothelial cells in | 717 |
C3 Axons and neurons in coronavirusindued demyelination 737 | 736 |
C4 The role of T cells in coronavirus induced demyelination | 747 |
C5 The role of humoral immunity in mouse hepatitis virus 759 | 758 |
C6 The role of T cell epitopes in coronavirus infection | 771 |
myelin proteins myelin 781 | 780 |
C9 Chemokines in coronavirusinduced demyelination 805 | 804 |
C10 Coronavirus receptors | 821 |
C11 Apoptosis in MHVinduced demyelination | 833 |
C13 Molecular determinants in coronavirus MHVinduced | 849 |
D1 Semliki Forest Virusinduced demyelination | 861 |
D2 The pathogenesis of canine distemper virus induced | 871 |
Index 889 | 888 |