Experimental Models of Multiple SclerosisEhud Lavi, Cris S. Constantinescu Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it. |
From inside the book
Results 1-5 of 69
... pathogenesis and for testing the safety and efficacy of experimental therapies before using these drugs in clinical trials on human patients . The main experimental models for MS are divided into immune - mediated models or virus ...
... pathogenesis of MS . The analysis of common features in the various experimental models of demyelination may also stimulate the development of new ideas about prevention of demyelination and ultimately the treatment of MS . Ehud Lavi ...
... pathogenesis of the disease . This procedure avoids local and systemic side effects of adjuvant - based immunizations . Treatment protocols could interfere with the efficacy of autoantigen immunization rather than reflect the effects on ...
... pathogenesis are most likely to be of the IFNy producing Thl subset , although it has been shown that Th2 cells may ... pathogenic mechanisms ( Luchinetti et al . , 2000 ) . In classical MS , several broad ' stages ' of the plaque lesion ...
... pathogenesis of MS has been proposed ( Anthony et al . , 2000 ) . The exact aetiology of MS is unknown , although a role for T - cells is suggested by histopathological analysis of MS lesions , and this has been more specifically ...
Contents
10 | |
25 | |
45 | |
73 | |
A6 The role of astrocytes in autoimmune disease of the central | 85 |
A7 Role of microglia and macrophages in EAE | 109 |
A8 The Neuron and axon in EAE 133 | 132 |
A9 Endothelial cells and adhesion molecules in EAE | 151 |
A27 EAE in primates | 561 |
B1 Histopathology in the Theilers virus model of demyelination 579 | 578 |
myelin genes and proteins | 593 |
B3 The role of astrocytes oligodendrocytes microglia and | 617 |
B4 Immunogenetics resistance and susceptibility to Theilers | 629 |
B5 The role of T cells and the innate immune system in Theilers | 645 |
B6 Cytokines chemokines and adhesion molecules in 659 | 658 |
B7 Molecular determinants of TMEV pathogenesis | 673 |
A10 Genetics of EAE | 180 |
Insights into the development and | 201 |
A12 The role of complement in EAE 245 | 244 |
A13 B cells and antibodies in EAE | 269 |
A14 Cytokines in EAE 283 | 282 |
A15 The role of interferons in EAE | 313 |
A16 The role of growth factors in EAE | 343 |
A17 The chemokine system in EAE 363 | 362 |
A18 Free radicals and EAE | 379 |
A19 Proteases and peptidases in EAE | 391 |
A20 The bloodbrainbarrier in EAE 415 | 414 |
altered peptide ligands | 451 |
A22 The role of costimulation in EAE | 471 |
A23 Epitope spreading in EAE | 491 |
apoptosis of effector cells as a 507 | 506 |
A25 Environmental influences in EAE | 523 |
A26 Hormonal and gender influences on EAE | 547 |
B8 Nitric oxide in TMEV 685 | 684 |
B9 Theilers murine encephalomyelitis virus TMEVinduced | 697 |
C1 Histopathology in coronavirusinduced demyelination | 711 |
C2 The role of astrocytes microglia and endothelial cells in | 717 |
C3 Axons and neurons in coronavirusindued demyelination 737 | 736 |
C4 The role of T cells in coronavirus induced demyelination | 747 |
C5 The role of humoral immunity in mouse hepatitis virus 759 | 758 |
C6 The role of T cell epitopes in coronavirus infection | 771 |
myelin proteins myelin 781 | 780 |
C9 Chemokines in coronavirusinduced demyelination 805 | 804 |
C10 Coronavirus receptors | 821 |
C11 Apoptosis in MHVinduced demyelination | 833 |
C13 Molecular determinants in coronavirus MHVinduced | 849 |
D1 Semliki Forest Virusinduced demyelination | 861 |
D2 The pathogenesis of canine distemper virus induced | 871 |
Index 889 | 888 |