Experimental Models of Multiple SclerosisEhud Lavi, Cris S. Constantinescu Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it. |
From inside the book
Results 1-5 of 86
... antibody specific for MOG , given eight days after immunisation with MBP in CFA ( Schluesener et al . , 1988 ) , or at the time of onset of passively induced disease ( Linington et al . , 1988 ) , providing further evidence for synergy ...
... antibodies directed against a myelin / oligodendrocyte glycoprotein . American Journal of Pathology 130 : 443-454 ... antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein ...
... antibody mediation . Annals of Neurology 46 : 144-160 . Ransohoff RM , 1999. Mechanisms of inflammation in MS tissue : adhesion molecules and chemokines . Journal of Neuroimmunology 98 : 57-68 . Ransohoff RM , Howe CL and Rodriguez M ...
... antibodies . However , most of the traditional adjuvants are of bacterial origin . It is not surprising that bacteria ... antibody production [ 1 ] led to the use of antigen - adjuvant combination emulsified in oil . The oil may play the ...
... antibodies . Several additional adjuvants have been tested for their ability to induce monoclonal antibodies in mice with some , such as GERBU adjuvant producing titers of antibodies similar to Freund's adjuvant and poly ( A ) .poly ( U ) ...
Contents
10 | |
25 | |
45 | |
73 | |
A6 The role of astrocytes in autoimmune disease of the central | 85 |
A7 Role of microglia and macrophages in EAE | 109 |
A8 The Neuron and axon in EAE 133 | 132 |
A9 Endothelial cells and adhesion molecules in EAE | 151 |
A27 EAE in primates | 561 |
B1 Histopathology in the Theilers virus model of demyelination 579 | 578 |
myelin genes and proteins | 593 |
B3 The role of astrocytes oligodendrocytes microglia and | 617 |
B4 Immunogenetics resistance and susceptibility to Theilers | 629 |
B5 The role of T cells and the innate immune system in Theilers | 645 |
B6 Cytokines chemokines and adhesion molecules in 659 | 658 |
B7 Molecular determinants of TMEV pathogenesis | 673 |
A10 Genetics of EAE | 180 |
Insights into the development and | 201 |
A12 The role of complement in EAE 245 | 244 |
A13 B cells and antibodies in EAE | 269 |
A14 Cytokines in EAE 283 | 282 |
A15 The role of interferons in EAE | 313 |
A16 The role of growth factors in EAE | 343 |
A17 The chemokine system in EAE 363 | 362 |
A18 Free radicals and EAE | 379 |
A19 Proteases and peptidases in EAE | 391 |
A20 The bloodbrainbarrier in EAE 415 | 414 |
altered peptide ligands | 451 |
A22 The role of costimulation in EAE | 471 |
A23 Epitope spreading in EAE | 491 |
apoptosis of effector cells as a 507 | 506 |
A25 Environmental influences in EAE | 523 |
A26 Hormonal and gender influences on EAE | 547 |
B8 Nitric oxide in TMEV 685 | 684 |
B9 Theilers murine encephalomyelitis virus TMEVinduced | 697 |
C1 Histopathology in coronavirusinduced demyelination | 711 |
C2 The role of astrocytes microglia and endothelial cells in | 717 |
C3 Axons and neurons in coronavirusindued demyelination 737 | 736 |
C4 The role of T cells in coronavirus induced demyelination | 747 |
C5 The role of humoral immunity in mouse hepatitis virus 759 | 758 |
C6 The role of T cell epitopes in coronavirus infection | 771 |
myelin proteins myelin 781 | 780 |
C9 Chemokines in coronavirusinduced demyelination 805 | 804 |
C10 Coronavirus receptors | 821 |
C11 Apoptosis in MHVinduced demyelination | 833 |
C13 Molecular determinants in coronavirus MHVinduced | 849 |
D1 Semliki Forest Virusinduced demyelination | 861 |
D2 The pathogenesis of canine distemper virus induced | 871 |
Index 889 | 888 |