Endocrine ToxicologyJohn A. Thomas, Howard D. Colby This text presents a range of topics from the molecular events surrounding hormone actions to epidemiologic studies of the effects of environmental and occupational chemicals on reproductive organs. The endocrine systems covered include the adrenal cortex, thyroid and parathyroid, gonads, and the endocrine pancreas. Of particular importance are the |
Contents
| 1 | |
Physiology of the Thyroid Gland and Agents Affecting Its Secretion | 43 |
ChemicallyInduced Changes in the Thyroid | 69 |
Toxicology of the Adrenal Cortex Role of Metabolic Activation | 81 |
ChemicallyInduced Lesions in the Adrenal Cortex | 115 |
Steroid Receptors | 133 |
Xenoestrogens and Estrogen Receptor Action | 181 |
Cellular and Molecular Effects of AndrogenicAnabolic Steroids | 213 |
Role of Cadmium in the Etiology of Cancer of the Prostate | 227 |
Actions of Chemicals and Other Factors on Leydig Cell Growth and Proliferation | 245 |
Toxic Effects of Cyproheptadine and Its Analogs in InsulinProducing Cells | 257 |
Epidemiologic Evidence for Toxic Effects of Occupational and Environmental Chemicals on the Testes | 287 |
Subject Index | 327 |
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Common terms and phrases
acrylonitrile action activity adenomas adrenal cortex adrenocortical alterations amino acid anabolic androgen receptor animals associated binding Biochem Biol biological blood cadmium calcium carcinogenic cellular Chem chemicals chief cells chronic Clin clinical compounds concentrations cytochrome cytoplasmic DBCP decreased doses drug effects endocrine Endocrinology endoplasmic reticulum Environ Health enzymes estrogen receptor exposed exposure factors fetal follicle cells function gene glucocorticoid receptor human hypercalcemia hyperplasia increased induced inhibition insulin iodide iodine lesions levels Leydig cell lipid mechanism membrane metabolism metabolites mice Natl necrosis normal osteoclasts pancreatic parathyroid glands parathyroid hormone Pharmacol phytoestrogens plasma PPImRNA production progesterone receptor prostate cancer protein PTHrP rats renal response secretion secretory semen serum specific sperm counts spironolactone steroid hormones stimulation structure studies synthesis testicular testosterone thyroglobulin thyroid gland thyroid hormone tion tissue toxicity Toxicol Toxicology treatment ultrastructural vitamin vitamin D vitro vivo workers xenobiotic xenoestrogens zona
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