AutoantibodiesYehuda Shoenfeld, M. Eric Gershwin, M.E. Gershwin, Pier Luigi Meroni Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person’s own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus. The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person’s body. Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease.
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From inside the book
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Page 8
... cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen was shown to promote B-cell accumulation and serum autoantibody secretion. Thus, these B cells that ...
... cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen was shown to promote B-cell accumulation and serum autoantibody secretion. Thus, these B cells that ...
Page 10
... cells are phagocytosed by macrophages and dendritic cells that subsequently present these autoantigens to T cells. It is believed that autoantigens originating from ingestion of apoptotic cells is one of the tolerizors that maintains an ...
... cells are phagocytosed by macrophages and dendritic cells that subsequently present these autoantigens to T cells. It is believed that autoantigens originating from ingestion of apoptotic cells is one of the tolerizors that maintains an ...
Page 11
... cells also provide atheroprotective qualities. B cell-LDL Receptor deficient mice have been generated by ... cells. In addition, splenectomy of ApoE_/_ mice, which was shown to decrease anti-OxLDL antibody titers, also resulted in ...
... cells also provide atheroprotective qualities. B cell-LDL Receptor deficient mice have been generated by ... cells. In addition, splenectomy of ApoE_/_ mice, which was shown to decrease anti-OxLDL antibody titers, also resulted in ...
Page 14
... cells known to be susceptible to permissive CMV infection express CD13, including all blood mononuclear cells (MNCs) as well as fibroblast, smooth muscle, epithelial, endothelial and certain neuronal cells. The virus is thought to ...
... cells known to be susceptible to permissive CMV infection express CD13, including all blood mononuclear cells (MNCs) as well as fibroblast, smooth muscle, epithelial, endothelial and certain neuronal cells. The virus is thought to ...
Page 29
... CELL SURFACE BINDING AND LYSIS (CYTOTOXICITY) BINDING TO CELL SURFACE RECEPTORS WITHOUT CYTOLYSIS IMMUNE COMPLEX–MEDIATED DAMAGE TRANSLOCATION OF INTRACELLULAR ANTIGENS TO CELL MEMBRANE PENETRATION INTO LIVING CELLS BINDING TO ...
... CELL SURFACE BINDING AND LYSIS (CYTOTOXICITY) BINDING TO CELL SURFACE RECEPTORS WITHOUT CYTOLYSIS IMMUNE COMPLEX–MEDIATED DAMAGE TRANSLOCATION OF INTRACELLULAR ANTIGENS TO CELL MEMBRANE PENETRATION INTO LIVING CELLS BINDING TO ...
Contents
83 | |
93 | |
127 | |
Part V Autoantibodies to Biologic FactorsStructures | 255 |
Part VI Cardiac Autoantibodies | 339 |
Part VII Endocrine Autoantibodies | 367 |
Part VIII GI and Liver Autoantibodies | 415 |
Part IX Hematologic Autoantibodies | 493 |
Part XI Neurological System Autoantibodies | 567 |
Part XII Rheumatic Disease Autoantibodies | 667 |
Part XIII Skin Disease Autoantibodies | 763 |
Part XIV Unique Clinical Situations | 781 |
Part XV Future Directions | 815 |
Index | 827 |
Color Plates | 839 |
Part X Kidney Autoantibodies | 545 |
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Common terms and phrases
2/e Copyright 2GPI affinity alpha-fodrin amino acids ANCA anti anti-DNA anti-dsDNA anti-tTG antibodies antigen antiphospholipid apoptosis assay associated atherosclerosis autoantibodies autoantigens autoimmune diseases B.V. All rights binding C3NeF cancer cells Clin CLINICAL UTILITY coeliac disease collagen correlation cytokines cytoplasmic diabetes diagnostic disease activity domain ELISA enzyme epitopes expressed factor function FVIII gangliosides gene genetic hepatitis histone HISTORICAL NOTES human identified idiotypes IgG1 immune complexes immune response immunoblotting immunofluorescence immunoglobulin Immunol indirect immunofluorescence induced markers membrane MESSAGES REFERENCES ABSTRACT mice molecular molecules monoclonal neurological normal nuclear nucleosome paraneoplastic pathogenic role patients peptides plasma platelet positive present prevalence protein purified reactivity receptor recombinant reported rheumatoid arthritis scleroderma sclerosis sensitivity sera serum Sjögren’s syndrome specific staining studies subunits systemic lupus erythematosus T1DM TAKE-HOME MESSAGES REFERENCES target thrombosis thyroid tissue titers tumor vasculitis VGCC vitro
Popular passages
Page 108 - Van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, van Es LA, van der Giessen M, van der Hem GK, The TH: Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis.
Page 18 - Fujinami RS, Oldstone MBA, Wroblewska Z, Frankel ME, Koprowski H. Molecular mimicry in virus infection: Crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Proc Natl Acad Sci USA 1983;80:2346-50. 106. Fujinami RS, Oldstone MBA. "Cross-reaction of measles virus phosphoprotein with a human intermediate filament: molecular mimicry during virus infection.
Page 744 - Harris EN, Gharavi AE, Boey ML et al. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus.
Page 101 - Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651-7.
Page 377 - Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347:151-6.
Page 386 - Effects of insulin in relatives of patients with type 1 diabetes mellitus.
Page 59 - Arbuckle MR, McClain MT, Rubertone MV, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003;349:1526-1533.
Page 363 - The causes of dilated cardiomyopathy: a clinicopathologic review of 673 consecutive patients. J Am Coll Cardiol 23(3):586-590 45.
Page 761 - On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles.
Page 125 - FJ (1998) Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis: EC/BCR project for ANCA assay standardization. Kidney Int 53: 743-753 Knight DA.
References to this book
Handbook of Human Immunology, Second Edition Maurice R.G. O'Gorman,Albert D. Donnenberg Limited preview - 2008 |