Animal Models of Cognitive ImpairmentEdward D. Levin, Jerry J. Buccafusco The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen |
Contents
| 1 | |
| 5 | |
3 Nicotinic Receptor Antagonists in Rats | 21 |
4 Involvement of the NMDA System in Learning and Memory | 37 |
5 Animal Models and the Cognitive Effects of Ethanol | 49 |
6 Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure | 73 |
Consequences Conditioning and Cortex | 101 |
What Animal Models Have Told Us | 147 |
10 Cognitive Impairment in Transgenic Mouse Models of Amyloid Deposition | 183 |
11 Cholinergic Receptor Knockout Mice | 199 |
12 Assessments of Cognitive Deficits in Mutant Mice | 223 |
13 Cognitive Pharmacology in Aging Macaques | 285 |
14 Cognitive Impairment following Traumatic Brain Injury | 301 |
15 Cognitive Impairment Models Using Complementary Species | 315 |
16 Cognition Models and Drug Discovery | 343 |
| 357 | |
9 Modeling Cognitive Deficits Associated with Parkinsonism in the ChronicLowDose MPTPTreated Monkey | 169 |
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acetylcholine acquisition agonist Alzheimer’s disease amygdala amyloid animal models antagonist Aroclor assessed attention Behav behavior brain injury Brain Res choice cholinergic cognitive cognitive deficits cognitive function cognitive impairment cortex cortical cues delay developmental discrimination reversal disruption dopamine dose drug dysfunction effects of ethanol ethanol exposed fear conditioning foot shock gene genetic gestation goldfish hippocampus human increased inhibition interval knockout latency lead exposure learning and memory lesions lever pressing Levin M1 mAChR mAChR KO mice mecamylamine MeHg memory deficits memory impairment methylmercury mg/kg monkeys Morris water maze motor mouse MPTP muscarinic mutant nAChR neural neurons Neurosci Neurotoxicol nicotinic nicotinic acetylcholine receptor NMDA receptor nonspatial observed PCB exposure performance Pharmacol pharmacological phenotype potential processes Psychopharmacology radial arm maze rats reinforcement response retention rodents role schedule schizophrenia scopolamine sensitivity session spatial learning stimulus studies task Teratol Toxicol transgenic transgenic mice trials visual zebrafish