Introduction to the Cellular and Molecular Biology of CancerLeonard Maurice Franks, Natalie M. Teich The third edition of this repected textbook has been extensively revised and updated by the authors and editors to achieve the same objectives as the two earlier editions -- to provide a relatively brief but comprehensive introduction to the initiation, development, and treatment of cancer.After an introduction describing the pathology and natural history of the disease, subsequent chapters survey particular areas of research, concentrating on the principles involved and recent developments. Each topic is reviewed authoritatively by acknowledged experts, in a way that will beunderstood by non-experts in the field.The chapters on epidemiology, genetic and chromosome changes, oncogenes, chemical and radiation carcinogenesis, growth factors, the biology of human leukaemia, and hormones and cancer have been rewritten and/or extensively revised and new developments resulting from the wide application of currenttechniques in cellular and molecular biology to the study of cancer are included. Other chapters have been revised and brought up to date, and new chapters are inclueed on cytokines and cancer, the molecular pathology of cancer, and cancer prevention and screening.Introduction to the Molecular and Celluar Bilogy of Cancer provides a general survey of the whole field of cancer as a basis for research and will serve as a valuable introduction to students and scientists new to the field. |
Contents
What is cancer? L M FRANKS 14233679 | 1 |
The spread of tumours I R HART | 21 |
Epidemiology of cancer T KEY D FORMAN AND M C PIKE | 34 |
Inherited susceptibility to cancer | 60 |
Structure of DNA and its relationship to carcinogenesis | 92 |
Chemical carcinogenesis | 106 |
Radiation carcinogenesis G E ADAMS AND R COX | 130 |
Viruses and cancer JOHN WYKE | 151 |
Hormones and cancer M G PARKER AND L M FRANKS | 274 |
The neuroendocrine system and its tumours | 299 |
Immunology of cancer PETER BEVERLEY | 311 |
The local treatment of cancer IAN FENTIMAN | 330 |
Chemotherapy J S MALPAS | 343 |
Monoclonal antibodies and therapy PHILIP E THORPE | 353 |
Cytokines and cancer FRANCES R BALKWILL | 380 |
Screening and chemoprevention JACK CUZICK | 392 |
Oncogenes and cancer NATALIE M TEICH | 169 |
Chromosomes and cancer DENISE SHEER | 202 |
Growth factor signalling pathways in cancer | 230 |
Stem cells haemopoiesis and leukaemia MEL GREAVES | 251 |
The molecular pathology of cancer | 264 |
Other editions - View all
Introduction to the Cellular and Molecular Biology of Cancer Leonard Maurice Franks No preview available - 1991 |
Common terms and phrases
aberrations abnormal activity agents allele amino acid animals antigen apoptosis associated binding biology blood bone marrow breast cancer carcinogenesis carcinogens carcinoma cell lines cell types cellular cent Chapter chemical chromosome clinical clone colon colorectal colorectal cancer cytokines cytotoxic detected differentiation disease domain dose drug effects encoding enzyme epithelial example expression function genetic genome growth factor hormones identified immune incidence increase induced infection inherited inhibit interaction involved lesions leukaemia liver lung cancer lymphocytes lymphoma malignant markers mechanisms membrane metastasis metastatic mice molecular molecules monoclonal antibodies mouse mutations neoplasia neoplastic normal cells oestrogen oncogene ovarian pathways patients peptides phenotype population potential prostate protein radiation rates receptor response retinoblastoma role sarcoma screening sequences SH2 domains signalling specific stem cells structure studies target techniques therapy tion tissue transcription factors transformation translocation treatment tumour cells tumour suppressor genes tyrosine kinase viral virus viruses vitro