Introduction to the Cellular and Molecular Biology of Cancer

Front Cover
Leonard Maurice Franks, Natalie M. Teich
Oxford University Press, 1997 - Medical - 458 pages
The third edition of this repected textbook has been extensively revised and updated by the authors and editors to achieve the same objectives as the two earlier editions -- to provide a relatively brief but comprehensive introduction to the initiation, development, and treatment of cancer.After an introduction describing the pathology and natural history of the disease, subsequent chapters survey particular areas of research, concentrating on the principles involved and recent developments. Each topic is reviewed authoritatively by acknowledged experts, in a way that will beunderstood by non-experts in the field.The chapters on epidemiology, genetic and chromosome changes, oncogenes, chemical and radiation carcinogenesis, growth factors, the biology of human leukaemia, and hormones and cancer have been rewritten and/or extensively revised and new developments resulting from the wide application of currenttechniques in cellular and molecular biology to the study of cancer are included. Other chapters have been revised and brought up to date, and new chapters are inclueed on cytokines and cancer, the molecular pathology of cancer, and cancer prevention and screening.Introduction to the Molecular and Celluar Bilogy of Cancer provides a general survey of the whole field of cancer as a basis for research and will serve as a valuable introduction to students and scientists new to the field.

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Contents

What is cancer? L M FRANKS 14233679
1
The spread of tumours I R HART
21
Epidemiology of cancer T KEY D FORMAN AND M C PIKE
34
Inherited susceptibility to cancer
60
Structure of DNA and its relationship to carcinogenesis
92
Chemical carcinogenesis
106
Radiation carcinogenesis G E ADAMS AND R COX
130
Viruses and cancer JOHN WYKE
151
Hormones and cancer M G PARKER AND L M FRANKS
274
The neuroendocrine system and its tumours
299
Immunology of cancer PETER BEVERLEY
311
The local treatment of cancer IAN FENTIMAN
330
Chemotherapy J S MALPAS
343
Monoclonal antibodies and therapy PHILIP E THORPE
353
Cytokines and cancer FRANCES R BALKWILL
380
Screening and chemoprevention JACK CUZICK
392

Oncogenes and cancer NATALIE M TEICH
169
Chromosomes and cancer DENISE SHEER
202
Growth factor signalling pathways in cancer
230
Stem cells haemopoiesis and leukaemia MEL GREAVES
251
The molecular pathology of cancer
264
Some conclusions and prospects ROBIN A WEISS
415
Glossary
427
Index
443
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About the author (1997)

L. M.FranksSenior Consulting Scientist.

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