OncogenesThe second edition of this authoritative text details major advances and developments in the field, such as the identification of many new tumor suppressor genes and the striking progress in understanding signal transduction pathways leading to cell proliferation. Oncogenes, Second Edition, addresses the needs of advanced undergraduates, graduate students, medical students, physicians, and scientists by examining the current state of oncogene study and where future research may lead. |
Contents
The Cancer Cell | 3 |
Tumor Viruses | 21 |
Retroviral Oncogenes | 37 |
CELLULAR ONCOGENES AND TUMOR | 67 |
Cellular Oncogene Targets for Retroviral | 85 |
Oncogenes and Chromosome Translocation | 99 |
Amplification of Oncogenes in Tumors | 113 |
Retinoblastoma and the Discovery of Tumor | 126 |
ProteinTyrosine Kinases and Growth Factor | 196 |
Guanine Nucleotide Binding Proteins | 222 |
ProteinSerineThreonine Kinases | 243 |
Transcription Factors | 255 |
Pathways of Mitogenic Signal Transduction | 279 |
Development Differentiation and Programmed | 323 |
New Prospects for Cancer Prevention | 347 |
Summary | 353 |
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Common terms and phrases
Acad acutely transforming amino acids amplification apoptosis avian Biol c-fos c-myc cancer carcinomas cell cycle cell line cell proliferation cell transformation cellular oncogenes chapter chromosome translocation culture cyclin deletion DNA binding erbB fibroblasts function fusion protein G proteins G₁ gene encoding gene product gene transfer genetic genome growth factor receptors guanine nucleotide homologous hormone human tumors identified inactivation induce inhibition interaction intracellular isolated kinase activity leukemia locus lymphomas mammalian MAP kinase mice mitogenic mouse mRNA mutations Natl Nature neoplasms normal cells oncogene activated oncogene protein pathway PDGF phosphorylation Proc protein kinase protein-tyrosine kinase proto-oncogene proviral provirus ras oncogenes Ras proteins receptor protein-tyrosine kinase receptor tyrosine kinases recombination regulation regulatory retinoblastoma retroviruses role sarcoma virus Science sequences SH2 domains signal transduction stimulation T-cell target tion transcription factor transformed cells transgenic tumor suppressor genes viruses vitro