Taxol: Science and ApplicationsMatthew Suffness This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic. |
From inside the book
Results 1-5 of 68
Page 9
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Page 10
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Page 11
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Page 12
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Page 16
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Contents
Chapter | 3 |
Chapter | 10 |
Chapter | 12 |
A Brief History of the Yew Tree | 27 |
Chapter 3 | 37 |
Chapter 4 | 71 |
Semisynthesis of Taxol and Taxotere | 97 |
Chapter 6 | 123 |
Chapter 8 | 209 |
Chapter 9 | 237 |
The Use of Taxol in Cell Biology | 259 |
Chapter 11 | 277 |
Chapter 12 | 287 |
The Medicinal Chemistry of Taxol | 317 |
Chapter 14 | 379 |
417 | |
Other editions - View all
Common terms and phrases
10-deacetylbaccatin 10-deacetylbaccatin III A-ring acid administered agents antitumor activity Approach assay baccata baccatin biological breast cancer C-ring callus carcinoma cell culture cell lines cephalomannine Chem chemical cisplatin Clin clinical compound concentrations Cremophor cycloaddition cytotoxicity derivatives dose drug effects ester esterification evaluation Figure formation formulation growth Guénard harvest infusion isolated leukemia liposomes metabolites methyl mg/m² mice microtubule murine Natl Oncol ovarian cancer oxetane oxidation Pacific yew Pacific yew bark Paclitaxel patients phase plant cell culture Potier precursor Proc prodrugs reaction Reagents and Conditions reported ring system schedule Scheme semisynthesis side chain solubility species ß-lactam structure studies taxane taxane production taxoids Taxol Taxol analogues Taxol and Taxotere Taxol and Taxus Taxol content Taxol side chain Taxotere Taxus baccata Taxus brevifolia Tetrahedron Lett therapy tissue toxicity treatment trials tubulin tumor models vitro vivo Workshop on Taxol yew trees yield