Fibrous Proteins: Coiled-Coils, Collagen and Elastomers, Volume 70

Front Cover
David A.D. Parry, John M. Squire
Gulf Professional Publishing, May 6, 2005 - Science - 544 pages
Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the first of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award winning issue of Journal of Structural Biology. Part II will contain an extensive discussion of Molecular Motors and Muscle, Part III on Amyloids, Prions and Beta Proteins.

Advances in Protein Chemistry is available online on ScienceDirect - full-text online of volumes 53 onwards.

  • Reveals new structural and functional aspects of fibrous proteins
  • Based on Fibrous Protein workshop in Alpbach, Austria that gave rise to 2003 Nobel Prize winners in Chemistry

From inside the book

Contents

Spectrin aActinin and Dystrophin
5
Structural and Functional Implications of Sequence
11
ANDREI N LUPAS AND MARKUS GRUBER
37
Microdissection of the Sequence and Structure of Intermediate
113
Summary
136
Intermediate Filament Associated Proteins
143
Cell SurfaceIF Interactions
159
Other Crosslinkers not in the Plakin Family
168
Collagen and Collagen Model Peptides
307
Mechanism of Hydroxyproline Stabilization
319
Breaks in the GlyXY Repeating Pattern
323
Ligand Binding
326
Mutations and Disease
329
Conclusions
332
References
333
Collagen Fibril Form and Function T J WESS
341

Motors that Move IFs
178
J F BRODERICK AND S J WINDER
203
Introduction
204
Evolution
205
Structure
208
Function
210
Regulations of Interactions
221
Disease
227
Conclusions
232
References
233
Fibrinogen and Fibrin JOHN W WEISEL
247
Introduction
248
Structure and Properties of Fibrinogen
251
Biosynthesis and Metabolism of Fibrinogen
260
Conversion of Fibrinogen to Fibrin
263
Binding of Other Proteins to Fibrin ogen
273
Fibrinolysis
275
Fibrinogen Binding to Integrins in Platelet Aggregation and Other Cellular Interactions
277
Dysfibrinogenemias Variants and Heterogeneity of Fibrinogen
279
Evolution of Fibrinogen and FibrinogenLike Domains
283
Conclusions
284
References
285
Molecular Structure of the Collagen Triple Helix BARABARA BRODSKY AND ANTON V PERSIKOV
301
Introduction
302
The Biological Role and Occurrence of the Collagen TripleHelix Motif in Proteins
303
Introduction
342
Fibrillar Molecular Packing
345
Lateral Packing in Fibrillar Collagens
350
Novel Fibrillar Structures
354
Subfibrillar Structures
356
Factors that May Regulate Fibril Growth and Size
357
Distribution of Fibril Sizes
359
Suprafibrillar Architectures
361
Mechnical Properties of CollagenRich Tissues
365
Conclusions
366
References
367
Molecular Packing in NetworkForming Collagens CARLO KNUPP AND JOHN M SQUIRE I Introduction
375
NetworkForming Collagens in Detail
377
The Type VI
392
Common Structural Themes in Networkforming Collagens
396
References
399
KIELTY MICHAEL J SHERRATT ANDREW MARSON AND CLAIR BALDOCK
405
Fibrillin Assembly
412
Fibrillin Microfibrils in Aging and Disease
426
MITHIEUX AND ANTHONY S WEISS
437
Properties of Elastin
446
AUTHOR INDEX
463
SUBJECT INDEX
507
Copyright

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