Built-in increases--The increases will provide: $407,000 for annualization of 1971 pay increase costs; $27,000 for one additional day of pay in 1972; $153,000 for within grade pay increases in 1972; $2,499,000 for changes in the amounts required to fund in 1972 those project grants which were funded in 1971 and are being continued in 1972 as a part of a commitment made prior to 1972.

Research grants--The net increase of $399,000 includes:

increases of $701,000

for new initiatives of high priority in research on arteriosclerotic and pulmonary diseases and $3,500,000 for basic and clinical research on Sickle

Explanation of Changes (continued)

Cell Anemia; as well as decreases of $1,618,000 for programs of lesser priority, $1,324,000 for the Heart Cooperative Drug Study, and $860,000 for general research support grants, a program included in each NIH appropriation containing research grant projects, but administered separately by the Division of Research Resources.

Fellowships--The request includes a decrease of $676,000 and an estimated decrease of 84 fellowship awards.

Laboratory and clinical research--The program increase of $118,000 and 11 positions will permit full implementation of the new Pulmonary Function Laboratory and for increased activity in the study of lipidosis and in coronary artery disease in conjunction with the Collaborative Research and Development program.

Collaborative research and development--The net program increase of $500,000 and 6 positions reflects increases of $1,500,000 for research on Sickle Cell disease and $2,000,000 for a detection, prevention, and evlauation program in the fields of respiratory disorders, lipidosis, and coronary artery disease; drug usage in patients with mild hypertension; and for research in blood storage, blood clots, and inherited blood disorders. These increases are partially offset by a $3,000,000 decrease of other Collaborative Research and Development programs of lesser priority.